Detalhe da pesquisa
1.
Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality.
Cell
; 158(5): 1199-1209, 2014 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25171417
2.
Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data.
Nucleic Acids Res
; 51(W1): W57-W61, 2023 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37178002
3.
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.
Nature
; 547(7664): 453-457, 2017 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28678785
4.
Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial.
J Intern Med
; 292(6): 925-940, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35934913
5.
Immediate Adaptation Analysis Implicates BCL6 as an EGFR-TKI Combination Therapy Target in NSCLC.
Mol Cell Proteomics
; 19(6): 928-943, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32234966
6.
The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia.
Am J Hematol
; 96(5): 580-588, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33625756
7.
Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.
Proc Natl Acad Sci U S A
; 114(30): E6231-E6239, 2017 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28701380
8.
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.
Mol Syst Biol
; 14(3): e7858, 2018 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29507054
9.
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
Nat Chem Biol
; 13(10): 1102-1108, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28805801
10.
Quantitative Interpretation of Intracellular Drug Binding and Kinetics Using the Cellular Thermal Shift Assay.
Biochemistry
; 57(48): 6715-6725, 2018 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30418016
11.
Reprint of: A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth.
Biochem Biophys Res Commun
; 499(2): 136-142, 2018 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29580626
12.
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Nat Chem Biol
; 12(2): 109-16, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26656090
13.
A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth.
Biochem Biophys Res Commun
; 494(3-4): 477-483, 2017 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29066348
14.
Discovery of a Small-Molecule Probe for V-ATPase Function.
J Am Chem Soc
; 137(16): 5563-8, 2015 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25860544
15.
Cancer-associated fibroblasts rewire the estrogen receptor response in luminal breast cancer, enabling estrogen independence.
Oncogene
; 43(15): 1113-1126, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38388711
16.
High-content screening of drug combinations of an mPGES-1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance.
Mol Oncol
; 18(2): 317-335, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37519014
17.
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells.
J Exp Clin Cancer Res
; 43(1): 107, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38594748
18.
Delineating functional and molecular impact of ex vivo sample handling in precision medicine.
NPJ Precis Oncol
; 8(1): 38, 2024 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38374206
19.
Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia.
Sci Rep
; 14(1): 4000, 2024 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38369625
20.
High-throughput cell spheroid production and assembly analysis by microfluidics and deep learning.
SLAS Technol
; 28(6): 423-432, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36990352